abstract：:Nutritional research in sickle cell disease has been the focus in recent times owing to not only specific nutritional deficiencies, but also the improvements associated with less painful episodes. Though hydroxyurea remains the drug of choice, certain adverse health effects on long term supplementation makes room for ...

journal_title：Nutrition & metabolism

authors： Khan SA,Damanhouri G,Ali A,Khan SA,Khan A,Bakillah A,Marouf S,Al Harbi G,Halawani SH,Makki A

更新日期：2016-08-08 00:00:00

abstract：BACKGROUND:Resveratrol is a natural polyphenol that has been proposed to improve glycemic control in diabetes, by mechanisms that involve improvement in insulin secretion and activity. In type 1 diabetes (T1D), in which insulin therapy is obligatory, resveratrol treatment has never been investigated. The present study ...

journal_title：Nutrition & metabolism

authors： Yonamine CY,Pinheiro-Machado E,Michalani ML,Freitas HS,Okamoto MM,Corrêa-Giannella ML,Machado UF

更新日期：2016-06-29 00:00:00

abstract：BACKGROUND:The objective of this study was to describe the intake of macronutrient, especially fatty acids, and explore their possible effect on diabetic retinopathy (DR) in patients with type 2 diabetes mellitus. METHODS:In this case-control study, we included a total of 146 patients with DR and 148 without DR. The i...

journal_title：Nutrition & metabolism

authors： Alcubierre N,Navarrete-Muñoz EM,Rubinat E,Falguera M,Valls J,Traveset A,Vilanova MB,Marsal JR,Hernandez M,Granado-Casas M,Martinez-Gonzalez D,Jurjo C,Franch-Nadal J,Vioque J,Mauricio D

更新日期：2016-06-04 00:00:00

abstract：BACKGROUND:From a health promotion perspective, the use of dietary indices is preferred above single nutrients and foods to evaluate diet quality. Longitudinal research about the association between dietary indices and respectively anthropometric parameters and blood lipids is lacking. The aim of this study was to inve...

journal_title：Nutrition & metabolism

authors： Mertens E,Deforche B,Mullie P,Lefevre J,Charlier R,Knaeps S,Huybrechts I,Clarys P

更新日期：2015-11-19 00:00:00

abstract：BACKGROUND:Cytokines secreted by adipose tissue macrophages (ATMs) significantly alter adipocyte function, inducing inflammatory responses and decreasing insulin sensitivity. However, little relevant information is available regarding the role of microvesicles (MVs) derived from ATMs in macrophage-adipocyte crosstalk. ...

journal_title：Nutrition & metabolism

authors： Zhang Y,Shi L,Mei H,Zhang J,Zhu Y,Han X,Zhu D

更新日期：2015-06-06 00:00:00

abstract：BACKGROUND:Diet-induced hepatic steatosis is highly associated with nonalcoholic fatty liver disease, which is related to the development of metabolic syndrome. While advanced stage nonalcoholic hepatic steatosis and steatohepatitis (NASH) result ultimately in fibrosis and cirrhosis, the molecular basis for lipid dropl...

journal_title：Nutrition & metabolism

authors： Shimada Y,Kuninaga S,Ariyoshi M,Zhang B,Shiina Y,Takahashi Y,Umemoto N,Nishimura Y,Enari H,Tanaka T

更新日期：2015-05-20 00:00:00

abstract：BACKGROUND:The aim of the present study was to examine the effects of onion as functional ingredient on the oxidative status, lipoprotein levels (total cholesterol-TC, HDL-C, LDL-C), triacylglycerides (TAG) and vascular reactivity of mesenteric arteries in hypercholesterolemic Wistar rats. METHODS:Twenty-four animals ...

journal_title：Nutrition & metabolism

authors： González-Peña D,Angulo J,Vallejo S,Colina-Coca C,de Ancos B,Sánchez-Ferrer CF,Peiró C,Sánchez-Moreno C

更新日期：2014-12-23 00:00:00

abstract：BACKGROUND:Protein energy malnutrition is commonly associated with immune dysfunctions and is a major factor in susceptibility to infectious diseases. METHODS:In this study, we evaluated the impact of protein energy malnutrition on the capacity of monocytes and macrophages to upregulate arginase, an enzyme associated ...

journal_title：Nutrition & metabolism

authors： Corware K,Yardley V,Mack C,Schuster S,Al-Hassi H,Herath S,Bergin P,Modolell M,Munder M,Müller I,Kropf P

更新日期：2014-10-24 00:00:00

abstract：BACKGROUND:A number of different pathways to obesity with different metabolic outcomes are recognised. Prenatal undernutrition in rats leads to increased fat deposition in adulthood. However, the form of obesity is metabolically distinct from obesity induced through other pathways (e.g. diet-induced obesity). Previous ...

journal_title：Nutrition & metabolism

authors： Thompson N,Huber K,Bedürftig M,Hansen K,Miles-Chan J,Breier BH

更新日期：2014-10-18 00:00:00

abstract：BACKGROUND:Recent data suggest that an increased level of high-density lipoprotein cholesterol (HDL-C) is not causally protective against heart disease, shifting focus to other sub-phenotypes of HDL. Prior work on the effects of dietary intakes has focused largely on HDL-C. The goal of this study was to identify the di...

journal_title：Nutrition & metabolism

authors： Kim DS,Burt AA,Ranchalis JE,Jarvik LE,Eintracht JF,Furlong CE,Jarvik GP

更新日期：2014-09-15 00:00:00

abstract：BACKGROUND:Fasting is a rigorous type of dietary restriction that is associate with a number of health benefits. During fasting, ketone bodies significantly increase in blood and become major body fuels, thereby sparing glucose. In the present study, we investigated effects of fasting on hypersensitivity. In addition, ...

journal_title：Nutrition & metabolism

authors： Nakamura S,Hisamura R,Shimoda S,Shibuya I,Tsubota K

更新日期：2014-08-28 00:00:00

abstract：BACKGROUND:Obesity is a major risk factor for insulin resistance, type 2 diabetes, and stroke. Flavonoids are effective antioxidants that protect against these chronic diseases. In this study, we evaluated the effects of sudachitin, a polymethoxylated flavonoid found in the skin of the Citrus sudachi fruit, on glucose,...

journal_title：Nutrition & metabolism

authors： Tsutsumi R,Yoshida T,Nii Y,Okahisa N,Iwata S,Tsukayama M,Hashimoto R,Taniguchi Y,Sakaue H,Hosaka T,Shuto E,Sakai T

更新日期：2014-07-04 00:00:00

abstract：:Nutrition & Metabolism has grown considerably in the ten years since its first article was published. To see how papers published in the journal had an impact we have identified some of the most popular articles in order to measure their influence, observe which fields are important to our readers, and try to explain ...

journal_title：Nutrition & metabolism

authors： Hussain MM,Abel L,Bakillah A

更新日期：2014-03-19 00:00:00

abstract：BACKGROUND:Omega-3 polyunsaturated fatty acids (n-3 PUFA) have been shown to alleviate the symptoms of metabolic disorders, such as heart disease, diabetes, obesity and insulin resistance. Several putative mechanisms by which n-3 PUFA elicit beneficial health effects have been proposed; however, there is still a shorta...

journal_title：Nutrition & metabolism

authors： Ahmed AA,Balogun KA,Bykova NV,Cheema SK

更新日期：2014-01-17 00:00:00

abstract：BACKGROUND:Elevated homocysteine is a cardiovascular risk factor in hyperlipidemia. Transsulfuration pathway provides an endogenous pathway for homocysteine conversion to antioxidant glutathione (GSH). Salvianolic acid A (Sal A) contains two molecules of caffeic acid and one molecule of danshensu that is capable of enh...

journal_title：Nutrition & metabolism

authors： Zhang W,He H,Wang H,Wang S,Li X,Liu Y,Jiang H,Jiang H,Yan Y,Wang Y,Liu X

更新日期：2013-12-06 00:00:00

abstract：BACKGROUND:The protective effect of HDL is mostly attributed to their metabolic function in reverse cholesterol transport (RCT), a process whereby excess cellular cholesterol is taken up from peripheral cells, processed in HDL particles, and later delivered to the liver for further metabolism and biliary secretion. Mec...

journal_title：Nutrition & metabolism

authors： Lichtenstein L,Serhan N,Annema W,Combes G,Robaye B,Boeynaems JM,Perret B,Tietge UJF,Laffargue M,Martinez LO

更新日期：2013-11-06 00:00:00

abstract：BACKGROUND:Currently, there is a lack of studies examining the effects of adenosine-5'-triphosphate (ATP) supplementation utilizing a long-term, periodized resistance-training program (RT) in resistance-trained populations. Therefore, we investigated the effects of 12 weeks of 400 mg per day of oral ATP on muscular ada...

journal_title：Nutrition & metabolism

authors： Wilson JM,Joy JM,Lowery RP,Roberts MD,Lockwood CM,Manninen AH,Fuller JC,De Souza EO,Baier SM,Wilson SM,Rathmacher JA

更新日期：2013-09-22 00:00:00

abstract：BACKGROUND:Although evidence indicates that fatty acids (FA) can affect insulin resistance (IR), not all FA contribute equally to the process. Indeed, monounsaturated FA (MUFA) and polyunsaturated FA (PUFA) are reported to reduce IR, whereas saturated FA (SFA) and trans FA appear to increase IR. However, it is not yet ...

journal_title：Nutrition & metabolism

authors： Ralston JC,Zulyniak MA,Nielsen DE,Clarke S,Badawi A,El-Sohemy A,Ma DW,Mutch DM

更新日期：2013-06-17 00:00:00

abstract：BACKGROUND:Supplementation studies have suggested a role of n-3 polyunsaturated fatty acids (PUFAs) in homocysteine metabolism, but the evidence is limited and inconsistent among studies that measured blood levels of n-3 and n-6 PUFAs. We examined the association between blood levels of PUFAs and homocysteine in Japane...

journal_title：Nutrition & metabolism

authors： Kume A,Kurotani K,Sato M,Ejima Y,Pham NM,Nanri A,Kuwahara K,Mizoue T

更新日期：2013-06-10 00:00:00

abstract：UNLABELLED: BACKGROUND:Leptin-deficient ob/ob mice exhibit adipocyte hypertrophy and hyperplasia as well as elevated adipose tissue and systemic inflammation. Multipotent stem cells isolated from adult adipose tissue can differentiate into adipocytes ex vivo and thereby contribute toward increased adipocyte cell numbe...

journal_title：Nutrition & metabolism

authors： Zhou Z,Neupane M,Zhou HR,Wu D,Chang CC,Moustaid-Moussa N,Claycombe KJ

更新日期：2012-12-05 00:00:00

abstract：UNLABELLED: BACKGROUND:It has been suggested that Sorghum, a rich source of phytochemicals, has a hypoglycemic effect, but the mechanism is unknown. We investigated the effects of oral administration of sorghum extract (SE) on hepatic gluconeogenesis and the glucose uptake of muscle in streptozotocin-induced diabetic ...

journal_title：Nutrition & metabolism

authors： Kim J,Park Y

更新日期：2012-11-27 00:00:00

abstract：: Calorie restriction (CR; ~60% of ad libitum, AL intake) has been associated with substantial alterations in body composition and insulin sensitivity. Recently, several proteins that are secreted by nontraditional endocrine tissues, including skeletal muscle and other tissues, have been discovered to modulate energy m...

journal_title：Nutrition & metabolism

authors： Sharma N,Castorena CM,Cartee GD

更新日期：2012-10-15 00:00:00

abstract：UNLABELLED: BACKGROUND:It is difficult to study the mechanisms of the metabolic syndrome in humans due to the heterogeneous genetic background and lifestyle. The present study investigated changes in the gene and protein profiles in an animal model of the metabolic syndrome to identify the molecular targets associated...

journal_title：Nutrition & metabolism

authors： Chang J,Oikawa S,Ichihara G,Nanpei Y,Hotta Y,Yamada Y,Tada-Oikawa S,Iwahashi H,Kitagawa E,Takeuchi I,Yuda M,Ichihara S

更新日期：2012-09-21 00:00:00

abstract：: A large volume of human clinical data supports increased dietary protein for favorable changes to body composition, but not all data are conclusive. The aim of this review is to propose two theories, "protein spread theory" and "protein change theory" in an effort to explain discrepancies in the literature. Protein s...

journal_title：Nutrition & metabolism

authors： Bosse JD,Dixon BM

更新日期：2012-09-12 00:00:00

abstract：: Paraoxonase 1 (PON1) is a HDL-associated esterase/lactonase and its activity is inversely related to the risk of cardiovascular diseases. The aim of the present study was to evaluate the effect of a high-salt diet on serum PON1 activity in fructose-fed insulin-resistant rats. Adult male Fischer rats were initially di...

journal_title：Nutrition & metabolism

authors： Dornas WC,de Lima WG,Dos Santos RC,de Souza MO,Silva M,Diniz MF,Silva ME

更新日期：2012-06-27 00:00:00

abstract：BACKGROUND:Dehydroepiandrosterone (DHEA) is precursor of sex steroid hormone. We demonstrated that acute DHEA injection to type 1 diabetes model rats induced improvement of hyperglycemia. However, the effect of the combination of DHEA administration and exercise training on insulin resistance is still unclear. This stu...

journal_title：Nutrition & metabolism

authors： Sato K,Iemitsu M,Aizawa K,Mesaki N,Ajisaka R,Fujita S

更新日期：2012-05-30 00:00:00

abstract：BACKGROUND:DNA methylation is an epigenetic phenomenon that can modulate gene function by up or downregulation of gene expression. Vitamin B12 and folate pathways are involved in the production of S-Adenosylmethionine, the universal methyl donor. FINDINGS:Brain vitamin B12 concentration and global DNA methylation was ...

journal_title：Nutrition & metabolism

authors： Fernàndez-Roig S,Lai SC,Murphy MM,Fernandez-Ballart J,Quadros EV

更新日期：2012-05-18 00:00:00

abstract：: Impaired kidney function and chronic kidney disease (CKD) leading to kidney failure and end-stage renal disease (ESRD) is a serious medical condition associated with increased morbidity, mortality, and in particular cardiovascular disease (CVD) risk. CKD is associated with multiple physiological and metabolic disturb...

journal_title：Nutrition & metabolism

authors： Slee AD

更新日期：2012-04-26 00:00:00

abstract：BACKGROUND:Glutathione has a wide range of functions; it is an endogenous anti-oxidant and plays a key role in the maintenance of intracellular redox balance and detoxification of xenobiotics. Several studies have indicated that children with autism spectrum disorders may have altered glutathione metabolism which could...

journal_title：Nutrition & metabolism

authors： Main PA,Angley MT,O'Doherty CE,Thomas P,Fenech M

更新日期：2012-04-24 00:00:00

abstract：BACKGROUND:Two major risk factors for the onset of fatty liver disease are excessive alcohol intake and obesity, the latter being associated with non-alcoholic fatty liver disease (NAFLD). The aim of this study was to examine the effects of black rice extract (BRE) on hepatic steatosis and insulin resistance in high-fa...

journal_title：Nutrition & metabolism

authors： Jang HH,Park MY,Kim HW,Lee YM,Hwang KA,Park JH,Park DS,Kwon O

更新日期：2012-03-30 00:00:00

abstract：BACKGROUND:Low plasma high-density lipoprotein-cholesterol (HDL-c) level is commonly present in obesity and represents an independent cardiovascular risk factor. However, obese patients are a very heterogeneous population and the factors and mechanisms that contribute to low HDL-c remain unclear. The aim of this study ...

journal_title：Nutrition & metabolism

authors： Nogueira JP,Maraninchi M,Béliard S,Lorec AM,Berthet B,Bégu-Le Corroller A,Dubois N,Grangeot R,Mattei C,Gaudart J,Nicolay A,Portugal H,Vialettes B,Valéro R

更新日期：2012-03-13 00:00:00

abstract：: Microsomal triglyceride transfer protein (MTP) was first identified as a major cellular protein capable of transferring neutral lipids between membrane vesicles. Its role as an essential chaperone for the biosynthesis of apolipoprotein B (apoB)-containing triglyceride-rich lipoproteins was established after the reali...

journal_title：Nutrition & metabolism

authors： Hussain MM,Rava P,Walsh M,Rana M,Iqbal J

更新日期：2012-02-21 00:00:00

abstract：BACKGROUND:Recent data from this laboratory suggest that components of dairy foods may serve as activators of SIRT1 (Silent Information Regulator Transcript 1), and thereby participate in regulation of glucose and lipid metabolism. In this study, an ex-vivo/in-vitro approach was used to examine the integrated effects o...

journal_title：Nutrition & metabolism

authors： Bruckbauer A,Zemel MB

更新日期：2011-12-20 00:00:00

abstract：: Sphingomyelin synthase (SMS) sits at the crossroads of sphingomyelin (SM), ceramide, diacylglycerol (DAG) metabolism. It utilizes ceramide and phosphatidylcholine as substrates to produce SM and DAG, thereby regulating lipid messengers which play a role in cell survival and apoptosis. Furthermore, its product SM has ...

journal_title：Nutrition & metabolism

authors： Yeang C,Ding T,Chirico WJ,Jiang XC

更新日期：2011-12-14 00:00:00

abstract：BACKGROUND:Polycystic ovary syndrome (PCOS) is frequently associated with hypovitaminosis D. Vitamin D is endowed with pleiotropic effects, including insulin resistance (IR) and apoptotic pathway. Disruption of the complex mechanism that regulated ovarian apoptosis has been reported in PCOS. Phosphoprotein enriched in ...

journal_title：Nutrition & metabolism

authors： Savastano S,Valentino R,Di Somma C,Orio F,Pivonello C,Passaretti F,Brancato V,Formisano P,Colao A,Beguinot F,Tarantino G

更新日期：2011-11-23 00:00:00

abstract：BACKGROUND:Evidence indicates that dietary fats and physical activity influence bone health. The purpose of this study was to examine the effects of long-term aerobic exercise and omega-3 (N-3) supplementation on serum inflammatory markers, bone mineral density (BMD), and bone biomarkers in post-menopausal women. METH...

journal_title：Nutrition & metabolism

authors： Tartibian B,Hajizadeh Maleki B,Kanaley J,Sadeghi K

更新日期：2011-10-15 00:00:00

abstract：UNLABELLED:Insufficient calcium intake has been proposed to cause unbalanced energy partitioning leading to obesity. However, weight loss interventions including dietary calcium or dairy product consumption have not reported changes in lipid metabolism measured by the plasma lipidome. METHODS:The objective of this stu...

journal_title：Nutrition & metabolism

authors： Smilowitz JT,Wiest MM,Teegarden D,Zemel MB,German JB,Van Loan MD

更新日期：2011-10-05 00:00:00

abstract：OBJECTIVE:Many studies have shown that vegetarian diet has beneficial effects on the prevention of cardiovascular diseases. However, the effect of vegetarian diet on carotid intima-media thickness (IMT), as well as the association between IMT and duration of vegetarian diet, are still unclear. The present study aims to...

journal_title：Nutrition & metabolism

authors： Yang SY,Zhang HJ,Sun SY,Wang LY,Yan B,Liu CQ,Zhang W,Li XJ

更新日期：2011-09-19 00:00:00

abstract：BACKGROUND:Increasing evidence suggests that diets high in polyunsaturated fatty acids (PUFA) confer health benefits by improving insulin sensitivity and lipid metabolism in liver, muscle and adipose tissue. METHODS:The present study investigates metabolic responses in two different lines of mice either selected for h...

journal_title：Nutrition & metabolism

authors： Nuernberg K,Breier BH,Jayasinghe SN,Bergmann H,Thompson N,Nuernberg G,Dannenberger D,Schneider F,Renne U,Langhammer M,Huber K

更新日期：2011-08-11 00:00:00

abstract：BACKGROUND:Studies have shown that the excessive fructose intake may induce adverse metabolic effects. There is no direct evidence from epidemiological studies to clarify the association between usual amounts of fructose intake and the metabolic syndrome. OBJECTIVE:The aim this study was to determine the association o...

journal_title：Nutrition & metabolism

authors： Hosseini-Esfahani F,Bahadoran Z,Mirmiran P,Hosseinpour-Niazi S,Hosseinpanah F,Azizi F

更新日期：2011-07-12 00:00:00